Date of Completion

2025

Document Type

Thesis

Degree Name

Bachelor of Science in Medical Laboratory Science

Keywords

Burn, Wounds, Second-Degree, Healing, Rat, Axonopus compressus, Extract

Abstract

With an increase in fire incidents in recent years, different therapeutic agents have been administered to manage wound healing associated with burn injuries; however, particular conventional treatments have been shown to hinder the wound healing process and cause adverse effects. The objective of this study was to determine the potential of Axonopus compressus (A. compressus) leaf ethanolic extract in the re-epithelialization of second-degree burn wounds in a rat model. The methodology included a total of 15 albino rats being categorized into three groups, subjected to second-degree burn injuries via thermal contact, and receiving either silver sulfadiazine (positive control), no treatment (negative control), or A. compressus leaf ethanolic extract (treatment group) administered for 14 days. The rats were euthanized on day 15 post-burn and examined histologically, and the wound-contraction rates and histological characteristics were recorded and compared. The phytochemical results showed the extract to possess glycosides, flavonoids, and tannins, among other compounds, which are beneficial to wound healing. Through One-way ANOVA, mean wound-contraction rates presented no statistically significant difference between the positive control and treatment group but presented significant differences for each when compared to the negative control group (p< 0.05) for days 3, 7, and 14. The histological characteristics indicated that the treatment group exhibited the most advanced healing progression compared to the positive and negative control group, supported by histological scores and microscopic evaluation. These findings suggest that with future research and validation, A. compressus may be used as an alternative therapeutic agent for burn-wound management.

First Advisor

Clarence Witty Mendoza-Fenol, RMT, MSMT, AHI (AMT)

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