Date of Completion

2025

Document Type

Thesis

Degree Name

Bachelor of Science in Medical Laboratory Science

Keywords

Corchorus olitorius ethanolic extract, Ascaris suum adult worms, anthelmintic efficacy, phytochemical screening, in vitro worm mortality assay, percent mortality analysis, alternative plant- based treatment III

Abstract

Soil-transmitted helminths (STH) remain a major public health concern, with Ascaris infections being among the most prevalent. Due to emerging resistance to standard anthelmintic drugs, this study explored the in vitro anthelmintic potential of Corchorus olitorius (Saluyot) ethanolic leaf extract against Ascaris suum adult worms, a surrogate model for A. lumbricoides. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, and saponins. Worms were exposed to three extract concentrations (25 mg/mL, 37.5 mg/mL, and 50 mg/mL), and mortality was observed over 72 hours. While no statistically significant differences were found between treatment groups (p > 0.05), the 50 mg/mL concentration consistently showed the highest mortality rate, comparable to Mebendazole (p = 0.160). These results suggest that C. olitorius has promising anthelmintic activity and potential as an accessible alternative therapy. Further studies using higher concentrations, quantitative phytochemical analysis, and more replicates are recommended to validate and expand upon these finding.

First Advisor

Roan Joyce T. Cabalida, RMT

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