Antimicrobial properties of the ethanolic leaf extract of Cananga odorata (Ilang-Ilang) against Salmonella enterica serovar typhimurium

Date of Completion

2023

Document Type

Thesis

Degree Name

Bachelor of Science in Medical Laboratory Science

Keywords

Salmonella enterica serovar Typhimurium, Cananga odorata, antimicrobial properties

Abstract

The emergence of antimicrobial resistance among various microorganisms has become a serious health concern globally as it continually challenges the readily available drugs, as well as the healthcare system. Salmonella enterica serovar Typhimurium is one of the most potent gramnegative bacteria that may cause human infections, such as gastroenteritis, intestinal inflammation, and Salmonellosis. In addition to this, it has also become resistant to many antibiotics. This prompt the development of innovative antimicrobial agents that may help resolve the arising problem of bacterial resistance to antibiotics. Cananga odorata is a plant usually seen in Asian countries, which has been known to possess medicinal benefits. This study was designed to determine the efficacy of the varying concentrations of ethanolic C. odorata leaf extracts against S. typhimurium. The study utilized a quantitative approach and Kirby-Bauer disc diffusion assay and minimum inhibitory concentration (MIC) were performed in order to determine the antimicrobial activity and inhibitory effects of C. odorata against S. typhimurium. The findings of the study showed that the varying concentrations of the C. odorata leaf extracts were not able to inhibit against S. typhimurium, possibly due to the fact that the gram-negative bacteria possesses a lipopolysaccharide layer in its cell wall, which caused it to become more resistant to hydrophobic substances. Thus, the C. odorata leaf extracts were not able to inhibit the bacteria enough to exhibit its antimicrobial properties since it is oily in nature.

First Advisor

Maria Katrina B. Pilit

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