Phytochemical analysis and determination of the in Ovo cytotoxic effects of Phyllanthus niruri Linn. leaf extracts against Salmonella enteritidis

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Bachelor of Science in Biochemistry




Phyllanthus niruri Linn, locally known in the Philippines as sammsampalukan, is traditionally used as a herbal remedy for treating cough, fever, viral infections, bacterial infections, and many other illnesses. In this study, its methanolic leaf extracts were subjected into an egg-based assay, evaluating its cytotoxic effects against Salmonella enteritidis. The methanolic leaf extract of P. ninuri L. was found to contain phytochemicals such as: flavonoids, tannins, alkaloids, saponins, terpenoids and steroids in considerable amounts and cardiac glycosides in a lesser amount. These compounds are attributed for the therapeutic effects of the methanolic leaf extract. Moreover, the bactericidal effects of the extract were observed to be efficient at concentrations of 1 to 10 ug/mL as no mortality within these concentrations were absorved, however, embryonic death was observed at 50ug/mL of the extract mixed with bacterial suspension within 48 h of post-inoculation.

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