Treadmill stress test parameters among patients diagnoses with stable coronary artery disease on combination therapy of trimetazidine and different beta blockers

Publication Date

2020

Document Type

Research

Abstract

Fourteen (14) selected charts were included and reviewed based on the inclusion and exclusion criteria. All of the patients were diagnosed with stable coronary artery disease, on combination therapy of trimetazidine and beta blocker, and underwent exercise stress test at DLSUMC. In this study, 14 patients who were diagnosed with stable coronary artery disease, underwent treadmill stress test that have baseline and repeat outcome to compare. Four (4) groups were created in this study, trimetazidine combined with different beta blockers such as carvedilol (T-C), metoprolol (T-M), atenolol (T-A), bisoprolol (T-B), nebivolol (T-N). The age range is between 47 and 74 years old with a mean age of 59.3±7.33 years old, with 7 male patients (50%) and 7 female patients (50%) altogether. Majority of the patients are 61-67 years old, corresponding to 35.7% of the total number of patients. The common cardiovascular risk factors among patients with ischemic heart disease were hypertension 85.7% (n:12); dyslipidemia in 78.6% (n:11); diabetes mellitus in 50% (n:7), and smoking is 28.6% (n:4). Association and statistical difference among the different groups were not properly established because of inadequate sample size. In relation to the treadmill stress parameters, all groups when compared from baseline and repeat procedures showed no significant difference at ≥1 mm ST segment depression (mean difference: 0.95% CI: 0.799), exercise duration (mean difference: 0.95% CI: 0.330), functional capacity (mean difference: 0, 95% CI: 0.255) and myocardial oxygen uptake (mean difference: 0,95% CI: 0.551).

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