The accuracy of rapid diagnostic tests in the diagnosis of chikungunya fever : a meta-analysis

Publication Date

2014

Document Type

Research

Abstract

The objective of this study is to determine the accuracy of rapid diagnostic tests in the diagnosis of chikungunya fever. Participants of the study are diagnosed chikungunya fever using rapid diagnostic test in a population with clinical signs and symptoms. Meta analysis was done to assess the accuracy of rapid diagnostic test in the diagnosis of Chikungunya fever. Based on QUADAS for risk of bias, majority of the included studies were classified as low risk. The lowest risk of 100% (5 of 5 studies) was on Reference standard while the highest risk was observed on flow and timing at 20% (1 of 5 studies). Based on QUADAS for applicabilityt, the lower risk was on patient selection and reference standard 100% (5/5 studies). Unclear risk was observed on patient selection 20% (1 of 5 studies). As compared to RT PCR, rapid diagnostic test (SD bioline) is not a good indicator in ruling in and ruling out of chikungunya infection. On the other hand, rapid diagnostic tests, as compared to RT PCR and ELISA, are of excellent diagnostic value for chikungunya infection. Lastly, rapid diagnostic tests as compared to ELISA have a very good diagnostic accuracy. This meta analysis showed that rapid diagnostic tests in general has an excellent diagnostic value in diagnosing chikungunya infection with an AUC of 0.90 and Q value of 0.83.

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