Date of Completion

2023

Document Type

Thesis

Degree Name

Bachelor of Science in Pharmacy

Keywords

saba banana, pectin, peels, paracetamol tablets, pharmaceutical binder

Abstract

The study aimed to evaluate the effectiveness of the ripe saba banana peel pectin as a pharmaceutical binding agent in paracetamol tablet formulation. The pectin was extracted from the ripe saba banana peels and confirmed by phytochemical tests and Fourier-Transform Infrared (FTIR) analysis. Then, it was used in the paracetamol tablet formulation. During the in-process quality control tests, starch and pectin tablets passed all the tests such as the angle of repose, bulk density, tapped density, Hausner’s ratio, and Carr’s index. For the drug-excipient compatibility tests, there were no organoleptic changes for temperature and light conditions except for swelling on no light conditions on Day 7 and dissolution of tablets under different pH conditions. Based on the FTIR analysis, the notable change in peaks was seen on Day 7 for all tablets, due to the functional groups of starch and pectin binder that are affecting both hyperconjugation and rehybridization of different C-H bonds in the paracetamol. For the finished product quality control (FPQC) tests, both tablets passed the thickness and weight variation tests but did not pass the hardness and the in-vitro dissolution tests. For the friability test, only the pectin tablets passed the test while only the starch tablets passed the disintegration test. The results of these FPQC tests are attributed to the binding capacities of pectin since starch tablets have a shorter disintegration time and higher release of paracetamol. In comparison, the pectin tablets have a longer disintegration time and lower release of paracetamol. Therefore, the ripe saba banana peel pectin can be used as a pharmaceutical binder in paracetamol tablet formulation.

First Advisor

Darwin Japheth L. Eusebio

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