Evaluation of pectin from jackfruit peels (Artocarpus heterophyllus Lam. [Family moraceae]) as drug carrier of furosemide through solid dispersion technique

Date of Completion

6-2019

Document Type

Thesis

Degree Name

Bachelor of Science in Pharmacy

Keywords

Artocarpus, Pectins, Furosemide, jackfruit peels, Drug Carriers

Abstract

Pectin was extracted from jackfruit peels using 0.25% ammonium oxalate. Obtained pectin samples were characterized based on the following parameters: identification test based on USP29/NF24, methoxyl content (MC), galacturonic acid (GaIA) and Fourier Transform Infrared Spectroscopy (FTIR). The soild dispersion of pectin (SDP) was characterized using scanning electron microscope (SEM), FTIR, x-ray diffraction (XRD) and solubility profile was conducted at pre-determined time points at 0, 5, 10, 15, 30, 45 and 60 minutes. The study concluded that pectin extracted from jackfruit was classified as LM pectin which indicates its ability to form gel and be less viscous. This served as a drug carrier for furosemide through SD technique. Solubility profile through dissolution test showed that commercially availabel furosemide table dissolbed 75.559% of furosemide in one hour while pectin-furosemide solide dispersion showed relatively higher result that dissolved 85.509% of furosemide, therefore, enhanced the solubility of a poorly water-soluble drug, furosemide.

First Advisor

Romeo Luis F. Ramirez, RPh

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