Date of Completion
5-2019
Document Type
Thesis
Degree Name
Bachelor of Science in Pharmacy
Keywords
Plant Mucilage, Metformin, Phaseolus vulgaris, binder
Abstract
Using Sharma and Koul method, the yield of mucilage was found to be 12.52%. The granules were formulated by wet granulation method using the extracted mucilage as binder at 15%, 20%, 25% w/w concentrations. The study concluded that an increase in mucilage concentrage results in retardation of drug release. The dissolution and assay results did not pass the USP requirement for Metformin HCl extended release tablet due to possible excipient incompatibility and loss during manufacturing.
First Advisor
Leigh Don T. Villanueva
APA Citation
Alano, M. A. O., Antonio, C. A. G., Cruz, H. F. P., & Manalo, G. R. (2019, May). Extraction, characterization and evaluation of Phaseolus vulgaris seed mucilage as a binder affecting the release profile of metformin HCL tablets. [Bachelor's thesis, De La Salle Medical and Health Sciences Institute]. GreenPrints. https://greenprints.dlshsi.edu.ph/bsp/16/