Date of Completion

2023

Document Type

Thesis

Degree Name

Bachelor of Science in Medical Laboratory Science

Keywords

Clot lysis, thrombolytic activity, Allium cepa L. cv. group aggregatum, shallot, Streptokinase

Abstract

Thrombosis refers to the formation of a blood clot within a blood vessel. It is associated with conditions such as myocardial infarction, ischemic stroke, and deep vein thrombosis that may be affected by obesity, age, cholesterol levels, and similar risk factors. Thrombolytic agents are used to dissolve these clots and restore blood flow. A common fibrinolytic agent used is streptokinase. The present study endeavored to evaluate the in-vitro thrombolytic activity of Allium cepa L. cv. group Aggregatum (shallot) ethanolic extract. Shallots are plants of the Allium species that are known to possess bioactive compounds such as flavonoids, polyphenols, vitamins, and minerals that aid in its thrombolytic potential. Based on the results of the present study, the crude shallot ethanolic extract had a significantly greater in-vitro thrombolytic activity in comparison to distilled water as evident in their computed mean % clot lysis of 52.31 ± 0.68 and 38.58 ± 0.85, respectively. Moreover, a directly proportional relationship between the extract concentration and thrombolytic activity was also observed. The mean % clot lysis of the positive control, streptokinase was recorded to be 58.30 ± 0.66; its thrombolytic activity was noticeably better than that of the crude extract. Further studies may be done to isolate and amplify phytoconstituents that may improve the in-vitro thrombolytic activity of Allium cepa L. cv. group Aggregatum and similar medicinal plants.

First Advisor

Jomel B. Vasquez

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