In vivo antidepressant-like effect of ethanolic extract of sida rhombifolia leaves in ICR albino mice
Date of Completion
2017
Document Type
Thesis
Degree Name
Bachelor of Science in Radiologic Technology
Keywords
Antidepressive Agents, Ethanol, Plant Extracts
Abstract
The primary objective of this study was to evaluate the potential antidepressant-like effect of the ethanolic extract of Sida rhombofilia leaves. This is in response to the prevalence of major depressive disorder which affects 21% of the population and the adverse effects associated with taking antidepressants. The ethanolic extract of S. rhombolifia was administered to male Institute of Cancer research (ICR) albino mice in 650 mg/kg, 750 mg/kg and 850 mg/kg doses. The mice were subjected to antidepressant screening methods (i.e. forced swimming test and tail suspension test) wherein the duration of immobility was related to behavioral despair. A decrease in the duration of immobility indicated antidepressant-like effect as observed in the standard antidepressant fluoxetine (% immobility: 35.18±4.90 in FST and 19.444±1.61 in TST) to which all the different doses of the extract were compared. Results revealed that all three doses decreased the immobility of mice in both tests as compared to the control (p
APA Citation
Eje, E. J., Frani, J. H., & Gawaran, M. E. F. (2017). In vivo antidepressant-like effect of ethanolic extract of sida rhombifolia leaves in ICR albino mice. [Bachelor's thesis, De La Salle Medical and Health Sciences Institute]. GreenPrints. https://greenprints.dlshsi.edu.ph/bch/83/