Title

Anti-angiogenic activity of selected roasted coffee bean extracts using chick chorioallantoic membrane assay

Date of Completion

2018

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

Coffee.

Abstract

Angiogenesis, the formation of new blood cells, is essential for tumor growth, progression and metastasis. Epidemiological studies have shown that coffee consumption is associated with a low incidence of cancer. The coffee beans of C. arabica, C. liberica, C. excelsa and C. robusta were roasted were extracted using 80% ethanol as the solvent. To determine their anti-angiogenic activity, the extracts were subjected to chick chorioallantoic membrane assay with a concentration of 3 μg/mL, 30 μg/mL and 100 μg/mL. Among the four coffee species, C. liberica exhibited the highest anti-angiogenic activity with a percent inhibition of 67.31% at 3 μg/mL. Light roasted coffee samples presented the highest anti-angiogenic activity when compared to medium and dark roasted coffee samples, regardless of the concentration.

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