The accuracy of procalcitonin in the diagnosis of neonatal sepsis : a meta-analysis

Publication Date

2013

Document Type

Research

Abstract

A meta-analysis was carried out to assess the accuracy of the procalcitonin for the diagnosis of neonatal sepsis. Nineteen studies analysed a total of 2,275 neonates. Subgroup analysis show that procalcitonin is more accurate for late onset sepsis that early onset sepsis, cord sample than peripheral sample and immunochromatographic than immunoluminometric tests. On comparison of different diagnostic tests, IL-6 has the highest Q* value of (0.85) followed by procalcitonin (0.81) then CRP (0.77). IL-6 also had higher positive LR and lower negative LR compared to procalcitonin and CRP.

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