Title

Comparison of the anti-angiogenic effect of ethanolic extract of Garcinia mangostana (mangosteen) pericarp against trastuzumab using chorioallantoic membrane (CAM): an experimental study

Date of Completion

2017

Document Type

Thesis

Degree Name

Clinical Pharmacology

Keywords

Garcinia mangostana, Ethanol, Trastuzumab, Chorioallantoic Membrane

Abstract

The objective of this study was to compare the anti-angiogenic activity of 3 different concentrations of ethanol extract of Garcinia mangostana (mangosteen) pericarp with Trastuzumab and with distilled water on 10-day-old Ana luzonica (Philippine duck) eggs. Ten-day-old-duck eggs were treated with three (3) different concentrations of mangosteen (10ug/ml, 50ug/ml, 100ug/ml), Trastuzumab (100ppm), and distilled water. After an incubation period of 48 hours, the number of collaterals of chorioallantoic membrane in different treatment groups were compared and analyzed with a level of significance of 0.05 and a confidence interval of 95% via one-way-ANOVA followed by Tukey Test. Results revealed that all concentrations of mangosteen suppressed angiogenesis in a dose dependent manner, although insignificantly when compared to the negative control (distilled water). However, mangosteen extract with 50 ug/ml and 100 ug/ml concentrations were comparable to Trastuzumab, which can be attributed to α-Mangosteen. Therefore, with the correct dosage, Garcinia mangostana pericarp extract can be an alternative to standard anti-angiogenic medications.

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