Assessment of anti-angiogenic effect of Mangifera indica L. (mango) peel extract using chick chorioallantoic membrane (CAM) assay

Date of Completion

7-2019

Document Type

Research Project

Degree Name

Grade 12

Keywords

Angiogenesis Inhibitors, Mangifera, peel extract, CAM assay, chorioallantoic membrane

Abstract

Angiogenesis enables the migration and growth of malignant tumor cells through the foramtion of new blood vessels that may result to cancer, however, there are plants with anti-angiogenic effect. The research study entitled Assessment of Anti-Angiogenic Effect of Mangifera indica L. (Mango) Peel Extract using Chick Chorioalantoic Membrane (CAM) Assay aimed to assess the effectiveness of anti-angiogenic properties of mango peel extract using CAM Assay through the method of rotary evaporation; then the administered treatment concentrations were prepared in parts per million (PPM) - 1---ppm, 200-pp,, 300-ppm, and 400-ppm. The study utilized one-way analysis of variance (ANOVA) statistical test. The results showed that fewer number of primary blood vessels developed in the CAM with treatment than the control setup with no treatment specifically with the 300-pp, concentration that exhibits 8-20 number of primary blood vessels. Also, there was a significant difference among the different concentrations of mango extract to the CAM by 5% significance level. Therefore, the anti-angiogenic properties of mango peel are effective on decreasing the number of primary blood vessels. It is recommended to conduct a phytochemical analysis, to provide a comparison of the mango peel extract with a commercially available anti-angiogenic drug, and to compare the anti-angiogenic effect of the peel and the mesocarp of the mango.

First Advisor

Pancho E. Ercilla

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