Date of Completion

2023

Document Type

Research Project

Degree Name

Grade 12

Keywords

Angiogenesis, Carica papaya, Chorioallantoic Membrane (CAM), Euphorbia hirta, Momordica charantia

Abstract

Among the varied selection of plants utilized as herbal medicine in the Philippines, Carica papaya (Papaya), Euphorbia hirta (Tawa-tawa), and Momordica charantia (Ampalaya) were among the most known but had a lot of unidentified benefits in terms of medicinal uses and benefits. Hence, this study aims to determine the angiogenic effect of Carica papaya, Momordica charantia, and Euphorbia hirta Ethanolic Leaf Extract on the CAM of a ten-day-old duck embryo and determine if there is a significant difference in the angiogenic activity of the different concentrations (100 ppm, 200 ppm, and 300 ppm) of the selected plant extracts in comparison to the positive and negative control on the CAM of a ten-day-old duck embryo. An experimental method was used as the research method, wherein the main subjects were the 126 randomly selected duck eggs, Carica papaya Ethanolic Leaf Extract, Momordica charantia Ethanolic Leaf Extract, and Euphorbia hirta Ethanolic Leaf Extract with three varying concentrations (100 ppm, 200 ppm, and 300 ppm) along with positive and negative controls. The major blood vessels were manually counted after 48 hours of incubation after the administration of treatments. Upon observation, all the selected plant leaf extracts showed angiogenic activities. Results from the statistical analysis showed that the 200 ppm (T2) of Papaya leaf extract concentration showed the highest mean and significant difference compared to other concentrations. The researchers concluded the Carica papaya, Momordica charantia, and Euphorbia hirta ethanolic leaf extracts exhibit significant angiogenic activity on the CAM of the ten-day-old duck embryo.

First Advisor

Myra Michelle M. Mojica

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