5% Simvastatin Ointment as Treatment for Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects (CHILD) Syndrome in a 4-year-old Female: A Case Report

Authors

Denise Marie B. David, Philippine General Hospital
Koreen Blossom T. Chan, Philippine General Hospital
Carmela Augusta F. Dayrit-Castro, Philippine General Hospital

Publication Date

1-1-2024

Document Type

Article

Publication Title

Acta Medica Philippina

Abstract

A 4-year-old female with Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects (CHILD) syndrome, with a pathogenic variant of the NSDHL gene, c.130G>A (p.Gly44Ser), and unilateral right-sided erythematous verrucous plaques with scaling and ipsilateral limb defects, was started on 5% simvastatin ointment. It was applied twice daily for four months, with improvement already seen starting week 2. Monotherapy with 5% simvastatin ointment was able to decrease the thickness of the verrucous plaques seen in our patient, highlighting that the accumulation of toxic metabolites may play a more crucial role in its disease pathogenesis.

First Page

94

Last Page

99

APA Citation

David, D., Chan, K., & Dayrit-Castro, C. (2024). 5% Simvastatin Ointment as Treatment for Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects (CHILD) Syndrome in a 4-year-old Female: A Case Report. Acta Medica Philippina, 58(17), 94-99. https://doi.org/10.47895/amp.v58i17.9202