Pentacyclic Triterpenoids and Steroids from Voacanga megacarpa

Authors

Allan Patrick G. Macabeo, University of Santo Tomas, Manila
Katherine Yasmin M. Garcia, University of Santo Tomas, Manila
Claire Francis S. de Guzman, University of Santo Tomas, Manila
Warren S. Vidar, De La Salle Medical and Health Sciences Institute, Philippines
Scott G. Franzblau, University of Santo Tomas, Manila

Publication Date

1-1-2015

Document Type

Article

Publication Title

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Abstract

Chromatographic purification of the crude DCM-methanolic extract of the Philippine endemic medicinal plant, Voacanga megacarpa, afforded a 1:1 mixture of lupeol acetate (1) and β-amyrin acetate (1), and a 1:1 mixture of stigmasterol (3) and β-sitosterol (4). The compounds were identified through analysis of their NMR spectroscopic data and by comparison with reported literature data. This is the first report on the isolation and identification of these compounds from V. megacarpa. The crude DCM-methanolic and alkaloid extracts, and fractions (1 and 2) showed moderate inhibitory activity against Mycobacterium tuberculosis H37Rv (MIC50 = 64 μg/mL).

First Page

432

Last Page

435

APA Citation

Macabeo, A., Garcia, K., de Guzman, C., Vidar, W., & Franzblau, S. (2015). Pentacyclic Triterpenoids and Steroids from Voacanga megacarpa. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6(2), 432-435.