Date of Completion

2024

Document Type

Thesis

Degree Name

Bachelor of Science in Pharmacy

Keywords

Fenofibrate, microbeads, Sargassum spp., Sagassum polycystum C. Agardh, sodium alginate, sodium alginate microbeads

Abstract

Fenofibrate is used for the treatment of excessive cholesterol and triglyceride levels in the body. However, it was reported to have low and variable fed/fasted bioavailability after oral administration. Controlling the rate in which the drug is released will improve absorption, decrease dosing frequency, and improve compliance. The rate can be controlled by modifying the drug delivery systems of fenofibrate. One method being explored is using alginate microbeads as a drug delivery system. In tropical countries, alginate is naturally sourced from Sargassum spp.. Hence, this study aimed to extract sodium alginate from Sargassum polycystum C. Agardh as a delayed-release matrix in the formulation of fenofibrate-loaded microbeads. The sodium alginate was extracted using the calcium alginic process and was then used to formulate three concentrations (3PNAF, 6PNAF, and 9PNAF) of fenofibrate-loaded microbeads through external ionotropic gelation method. The extracted sodium alginate resulted in a total percentage yield of 3.608%, lower than the expected percentile of 17-27.6%. However, other quality control test specifications were met. In microbeads formulation, it was observed that a low concentration of extracted sodium alginate resulted in irregularly shaped microbeads with protruding tails. This suggests that a higher concentration of sodium alginate is necessary to formulate a microbead that meets the specifications. However, the three formulations showed varying results on quality control tests. Among the three concentrations, 9PNAF, which had the highest concentration of sodium alginate, showed the highest percentage in which the drug was entrapped. It can be concluded from the study that a delayed-release matrix for Fenofibrate-loaded microbeads can be formulated using extracted sodium alginate from Sargassum polycystum C. Agardh. Therefore, the entire process was feasible in a laboratory setting and demands further study to improve the drug delivery system.

First Advisor

Renz Angelo G. Bunquin

Download

Share

COinS