Antiangiogenic activity of annona muricata (guyabano) leaf extract
Date of Completion
Bachelor of Science in Medical Laboratory Science
Anona, Plant Extracts, Angiogenesis Inhibitors
This study used experimental research design. Ninety-six (96) duck embryos were inoculated with A. muricata 40 ug. paclitaxel 0.92 ug, bevacizumab 238 ug, and 0.2% dimethysulfoxide (DMSO), the latter serving as the negative control. Angiogenesis was evaluated by counting the branching points using the WIMASIS image analysis web-based system. Multiple comparisons within groups was done using Tukey-Kramer HSD test at an α of 0.05 with 80% statistical power. The results of the study showed that mean branching points for A. muricata, paclitaxel, bevacizumab and DMSO were 117.71, 9.29, 2.54 and 158.46. A muricata leaf extracts showed a significant difference with paclitaxel, Bevacizumab and DMSO. The study concluded that bevacizumab and paclitaxel are far better anti-angiogenic agents than A. muricata extracts on CAM assays.
Antiangiogenic activity of annona muricata (guyabano) leaf extract.
Bachelor of Science in Medical Laboratory Science.
Retrieved from https://greenprints.dlshsi.edu.ph/bsmls/13