Title

Antiangiogenic activity of annona muricata (guyabano) leaf extract

Date of Completion

2017

Document Type

Thesis

Degree Name

Bachelor of Science in Medical Laboratory Science

Keywords

Anona, Plant Extracts, Angiogenesis Inhibitors

Abstract

This study used experimental research design. Ninety-six (96) duck embryos were inoculated with A. muricata 40 ug. paclitaxel 0.92 ug, bevacizumab 238 ug, and 0.2% dimethysulfoxide (DMSO), the latter serving as the negative control. Angiogenesis was evaluated by counting the branching points using the WIMASIS image analysis web-based system. Multiple comparisons within groups was done using Tukey-Kramer HSD test at an α of 0.05 with 80% statistical power. The results of the study showed that mean branching points for A. muricata, paclitaxel, bevacizumab and DMSO were 117.71, 9.29, 2.54 and 158.46. A muricata leaf extracts showed a significant difference with paclitaxel, Bevacizumab and DMSO. The study concluded that bevacizumab and paclitaxel are far better anti-angiogenic agents than A. muricata extracts on CAM assays.

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