Antibiotic susceptibility of extended-spectrum beta-lactamase (ESBL)-producing klebsiella pneumonia from selected tertiary hospitals

Date of Completion

2017

Document Type

Thesis

Degree Name

Bachelor of Science in Medical Laboratory Science

Keywords

Klebsiella pneumonia, Anti-bacterial Agents

Abstract

This study used descriptive research design. Twenty five (250 isolates each were purchased from three (3) hospitals with a total of 75 k. pneumoniae isolates. Antimicrobial susceptibility in ESBL-producing klebsiella pneumonia was performed by disk diffusion method for screening. The antimicrobial disks used include: Amikacin, Ampicillin.Sulbactam, Amoxicillin/Clavulanic Acid, Cefazolin, Cefepime, Cefoxitin, Ceftazidime, Ceftriaxone, Cefuroxime Axetil, Cefuroxime, Ciproloxacin, Colistin, Ertapenem, Gentamicin, Imipenem, Levofloxacin, Meropenem, Nitrofurantoin, Piperacillin/Tazobactam, Tobramycin and Trimethoprin/Sulfamethoxazole. The results of the study showed that out of 75 isolates, 21 isolates were identified ESBL-producing bacteria. Antimicrobial disk diffusion showed that the aminoglycoside and carbapenems antibiotics were moderately resistant to K. pneumoniae. Cephalosporin antibiotics ceftazidime, cefazolin, and cefoxitin were moderately resistant while cefuroxime, ceftriaxone and cefepime were highly resistant to specie of pathogens used. In addition, penicillin and fluoroquinolones antibiotics were highly resistant to k. pneumoniae.

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