Title

Investigation of anti-anemic property of Euphorbia hirta ethanolic extract (Tawa tawa) among Phenylhydrazine induced rats

Date of Completion

2017

Document Type

Thesis

Degree Name

Clinical Pharmacology

Keywords

Anemia, Ethanol, Rats, Euphorbia

Abstract

This study aimed to determine the presence of a possible anti-anemic property of Euphorbia hirta, a medicinal plant with established reputation in treating various ailments, among phenylhydrazine induced rats. This study utilized 30 Wistar Albino rats, and after a 5-day acclimatization period, were grouped into three according to the dose of treatment received. Group I served as the negative control while rats belonging to Group II received 200 mg/kg dose of Euphorbia hirta crude extract. On the other hand, rats belonging to Group III were administered with 600 mg/kg dose of the extract. Blood samples were obtained via cardiac puncture and hematologic parameters were assessed by determining the red blood cells, hemoglobin and hematocrit levels. Data assessment of the p-values of the hematologic parameters were performed using one way ANOVA. However, although administration of both low and high dose of Euphorbia hirta crude extract showed a minimal increase in hematologic parameters, there was no significant increase in the levels red blood cell count, hemoglobin, and hematocrit statistically.

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