In-vitro comparison of the anthelmintic property of euphorbia hirta with mebendazole on ascaris suum : an experimental study

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Clinical Pharmacology


Anthelmintics, Euphorbia, Mebendazole, Ascaris suum


The study aimed to compare the anthelmintic activity of methanol extract of Euphorbia hirta with commercial antihelminth drug Mebendazole (Antiox) on Ascaris suum. An in-vitro study involved treatment of Ascaris suum with normal saline solution, 3 different concentration of Euphorbia hirta and Mebendazole. Antihelminthic property was determined by comparing the baseline time of paralysis and time of death of the helminths in different treatments. Methanol extract of Euphorbia hirta is widely used as a traditional medicine to treat abdominal diseases, skin diseases, and parasitic infection. Based on the study, it was concluded that Euphorbia hirta extract does have anthelminthic activity against Ascaris suum. Although there were no significant differences in anthelminthic activity among the 3 tested concentrations, the highest concentration (100%) had the least mean time of death. Thus, it was also concluded that 100% concentration of Euphorbia hirta.

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