Title

The screening of the anthelmintic activity of allium sativa, carica papaya, citrus nobilis, citrus maxima and citrofortunella microcarpa compared to Mebendazole in ascaris suum

Date of Completion

2017

Document Type

Thesis

Degree Name

Clinical Pharmacology

Keywords

Anthelmintics, Ascaris suum, Mebendazole, Citrus, Carica

Abstract

The study was done to assess the anthelmintic activity on bawang (Allium sativa bulb, papaya (Carica papaya) seeds), dalanghita (Citrus nobilis) peels, suha (Citrus maxima) peels, and calamansi (Citrofortunella microcarpa) peel extracts in comparison to Mebendazole against Ascaris suum. An experimental study was employed wherein three different concentrations of methanolic extracts (100%, 75% and 50%) of the plant parts were used in comparison to the standard drug (Mebendazole) to test the mean killing time and time of paralysis of Ascaris suum which was analyzed using multiple comparison ANOVA. Each treatment test was done in triplicates with a positive control of Mebendazole and negative control of Normal Saline Solution. Results showed that the three concentrations of C. papaya, A. sativa, C. nobilis, C. maxima extracts were equally as effective as Mebendazole, wherein the concentrations that were statistically significant were found to be 75% for C. papaya and 100% for A. sativa, C nobilis, C. maxima, and C. microcarpa. It was then concluded that the methanolic extracts of bawang (allium sativa) bulb, papaya (carica papaya) seeds, dalanghati (citrus nobilis) peels, suha (citrus maxima) peels and calamanse (citrofortunella microcarpa) peels have showed antihelminthic activity against Ascaris suum.

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