Title

Hepatoprotective effects of methanol extract caesalpinia pulcherrima on paracetamol induced hepatotoxicity on albino rats

Date of Completion

2017

Document Type

Thesis

Degree Name

Clinical Pharmacology

Keywords

Methanol, Toxicity, Paracetamol, Rats

Abstract

The objective of the study was to determine the hepatoprotective effects of Methanol Leaf Extract of Caesalpinia pulcherrima (Caballero) on paracetamol-induced hepatotoxicity in albino rats. This study had 3 groups with 3 albino rats in each group. The negative control group received 1g/kg body weight paracetamol and NSS. The positive control group received paracetamol 1 g/kg body weight and N-acetylcysteine 150 mg/kg (Fluimucil). The treatment group received 1g/kg paracetamol and 200 mg/kg of methanol extract of Caesalpinia pulcherrima (MECP per orem. A total of 9 rats was used in the experiment. Duration of the experiment was 12 days including the acclimatization. Methanol extract of Caesalpinia pulcherrima, a shrub that has been bound in recent studies to have strong evidence of anti-inflammatory and anti-oxidant and other beneficial properties, was evaluated for hepatoprotective effects against paracetamol-induced hepatotoxicity as an alternative to NAC treatment. Based on our study, Caesalpinia pulcherrima did not show any significant evidence that it has hepatoprotective properties against paracetamol induced hepatotoxicity. However, the researchers suggested further testing to be done on a different animal, preferably a non-rodent, as the preliminary results may have been affected due to the rat's resistance to hepatoxicity.

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