Title

In vitro analysis of the antibacterial properties of Muntigia calabura Linn. (Aratiles) leaf crude methanol extract against Enterobacter aerogenes and Klebsiella pneumoniae

Date of Completion

2017

Document Type

Capstone Project

Degree Name

Clinical Pharmacology

Keywords

Antibacterial Agents, Methanol, Enterobacter aerogenes, Klebsiella pneumoniae, Herbal Medicine

Abstract

This study aimed to determine the antibacterial property of Muntigia calabura against enterobacter aerogenes and klebsiella pneumoniae. An in-vitro study employed Kirby-Bauer disk susceptibility test to compare the effects of Muntingia calabura extract from meropenem and ceftriaxone against enterobacter aerogenes and klebsiella pneumoniae respectively. It was found out the presence of flavonoids and tannins were the most important phytochemicals that exhibit the antibacterial property of the M. calabura leaf crude methanol extract. The extract at its 75% and 100^ concentration was able to elicit zone of inhibition to test organisms wherein, has the most effect of K. pneumoniae which may be associated by the direct inhibitory effect of flavonoids to its DnaB helicare, thus, inhibiting growth. However, its antibacterial properties was not comparable to the currently available antibiotics in the market such as ceftriaxone and meropenem.

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