Efficacy of Lagenaria siceraria (bottle gourd) extracts in weight reduction of metabolically induced mus muscarinis (white mice)

Date of Completion


Document Type


Degree Name

Clinical Pharmacology


Lagernara, Mice, Weight Loss


The study was done on the effects of Lagenaria siceraria (bottle gourd) juice, introduced orally, on the weight gain and reduction of Mus musculus (albino mice) as compared to a negative control which is distilled water. The mice were fed with normal mouse feed mixed with commercially bought chicharon to simulate a high fat, high cholesterol diet. The mice were introduced to both the treatment and the negative control via gavage once a day for one week and their weights were noted every two days. The physical effects on the mice with regard to increase in birth were also observed qualitatively. There was no significant difference between the weights of the mic between the treatment and negative control groups for both the male (p=0.48066543) and female (p=0.141571102) with a confidence interval of 95%. There was also notable bloating in the abdominal area of the male mice, but not similar findings were seen in the female mice. Ultimately, the findings indicated that there were no notable effects on the weight gain of mice after exposure to Lagenaria siceraria (bottle gourd) juice after one week. Longer exposure may have an effect, but side effects such as bloating may have to be addressed before proceeding for periods longer than one week.

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