Antimicrobial properties of ethanolic crude extract of mangosteen pericarp (garcinia mangostana) against gram-positive bacteria (staphylococcus aureus and streptococcus pyogenes) and gram-negative bacteria (escherichia coli and salmonella enterica serovar typhi)

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Clinical Pharmacology


Anti-Infective Agents, Garcinia mangostana, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Salmonella typhi, Ethanol


This study aimed to determine the antimicrobial properties of mangosteen (Garcinia mangostana L.) ethanolic crude extract against gram positive (Staphylococcus aureus and Streptococcus pyogenes) and gram negative bacteria (Escherichia coli and Salmonella enterica serovar typhi). An analytic-experimental study wherein the research design used was randomized control trial (RCT). This was to assess the antimicrobial effect of Garcinia mangostana on gram-positive (Escherichia coli and Salmonella enterica serovar typhi). The effect of the different concentrations of the mangosteen pericarp crude extract had been determined through measurement of the zone inhibition and determination of the minimum inhibitory concentration. Mangosteen pericarp ethanolic crude extract inhibitory and bactericidal effects on gram positive species with a minimum inhibitory and bactericidal concentration of 1500 microgram/mL, on the other hand, it was not inhibitory or bactericidal against the gram-negative representative species.

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