Assessment of collagen versus non collagen coated anterior vaginal mesh in pelvic reconstructive surgery: Prospective study

Tsia Shu Lo, Chang Gung Memorial Hospital
Eileen Feliz M. Cortes, Chang Gung Memorial Hospital
Pei Ying Wu, Chang Gung Memorial Hospital
Yiap Loong Tan, Chang Gung Memorial Hospital
Ahlam Al-Kharabsheh, Chang Gung Memorial Hospital
Leng Boi Pue, Chang Gung Memorial Hospital


Objective To evaluate the sonologic and clinical outcome of collagen coated (CC) versus non-collagen coated (NC) anterior vaginal mesh (AVM) for pelvic organ prolapse (POP) surgery. Study design The study is a prospective observational study which included 122 patients who had symptomatic POP stage III and IV. AvaultaPlus™ (collagen coated, CC group) was compared to Perigee™ (non collagen coated, NC group). Introital ultrasound morphology, measure of neovascularization by color Doppler and clinical outcomes were assessed. Student t test was used for comparison of pre- and post-operation continuous data (p value of <0.05). Results A total of 110 (CC group = 50, NC group = 60) women completed the study. A woman in the CC group developed ureteral injury. Both groups had comparable morphologic and clinical outcomes however, the onset of changes in mesh thickness and neovascularization occurred earlier in the NC group (1 month) compared to the CC group (6 months to 1 year). Conclusion CC group was comparable to the NC group in terms of erosion rate, ultrasound and clinical assessment. Collagen coating may induce delayed inflammatory response however may also delay tissue integration. The onset of changes in mesh thickness and neovascularization may give us an insight toward utilization of collagen coated mesh for host-tissue integration.