Clinical, Dermoscopy and Histopathological features of Nevus Lipomatosus Cutaneous Superficialis: A Multi-Center Case Series of 10 Patients

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Journal of Asia Pacific Aesthetic Sciences


Nevus lipomatosus cutaneous superficialis (NLCS) is a rare benign hamartomatous skin condition of unknown etiology. Clinically, NLCS can be classified into two clinical types: 1) Classical HoffmanZurhelle or the multiple type and 2) solitary pedunculated type. Histopathologically, hematoxylin-eosin would reveal ectopic mature adipose tissues interspersed with thickened collagen bundles in the dermis separate from the subcutaneous fat which is pathognomonic of NLCS. Although the clinical diagnosis of such condition is straightforward, sometimes it can be mistaken for other skin-colored pedunculated skin lesions. The authors hope that the result of the case series will guide dermatologists in differentiating NLCS from other skin-colored pedunculated skin lesions. A good clinical eye together with histopathology remains to be the gold standard for the diagnosis of this skin condition. Excision remains to be one of the most effective treatments of choice with minimal recurrence. Other treatment modalities such as carbon dioxide laser excision and cryotherapy may also be offered.

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