A case of multiple endocrine neoplasia IIB in a Filipino

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Philippine Journal of Internal Medicine


A 28 year old Filipina was diagnosed to have multiple endocrine neoplasia (MEN) type 2b at age 22. At age 3, she had growth at the oral mucosa. Multiple neuromas were removed from the tongue and lips by reconstructive surgery at age 18. After a year, she underwent total thyroidectomy. Histopathology result was medullary thyroid carcinoma (MTC). Calcitonin levels done thereafter were elevated. At age 22, modified radical neck exploration revealed metastatic medullary carcinoma to the lymph nodes. Bilateral adrenalectomy showed pheochromocytoma and medullary hyperplasia. Thereafter, there was no rise in calcitonin levels since post-thyroidectomy values. She is presently doing well on L-thyroxine and cortisone acetate. The rest of the family were screened and found negative for MTC.

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