Effect of L-Carnitine on the Limitation of Infarct Size in One-Month Postmyocardial Infarction Cases: A Multicentre, Randomised, Parallel, Placebo-Controlled Trial
On the basis of biochemical, experimental and clinical studies reporting a favourable effect of L-carnitine in acute myocardial ischaemia, the capability of the compound to reduce the extent of necrotic area in patients with a confirmed diagnosis of acute myocardial infarction was evaluated. The effect of L-carnitine was determined using technetium-99m (Tc99m) SPECT (Single Photon Emission Tomography) imaging. L-carnitine was found to significantly increase myocardial viability in treated patients after 8 weeks' oral supplementation, in comparison with controls treated with placebo. The data suggest that L-carnitine may have a significant role in the treatment of patients after myocardial infarction.