Effect of L-Carnitine on the Limitation of Infarct Size in One-Month Postmyocardial Infarction Cases: A Multicentre, Randomised, Parallel, Placebo-Controlled Trial

K. G.C. Jacoba, Philippine Heart Center
R. F. Abarquez, Philippine Heart Center
G. O. Topacio, De La Salle Medical and Health Sciences Institute
M. T. Abola, Philippine Heart Center
V. B. Flores, Philippine Heart Center
J. M. Sison, Medical Corp.
V. Defensor, De La Salle Medical and Health Sciences Institute
D. Aliwalas, De La Salle Medical and Health Sciences Institute

Abstract

On the basis of biochemical, experimental and clinical studies reporting a favourable effect of L-carnitine in acute myocardial ischaemia, the capability of the compound to reduce the extent of necrotic area in patients with a confirmed diagnosis of acute myocardial infarction was evaluated. The effect of L-carnitine was determined using technetium-99m (Tc99m) SPECT (Single Photon Emission Tomography) imaging. L-carnitine was found to significantly increase myocardial viability in treated patients after 8 weeks' oral supplementation, in comparison with controls treated with placebo. The data suggest that L-carnitine may have a significant role in the treatment of patients after myocardial infarction.