Pentacyclic Triterpenoids and Steroids from Voacanga megacarpa
Research Journal of Pharmaceutical, Biological and Chemical Sciences
Chromatographic purification of the crude DCM-methanolic extract of the Philippine endemic medicinal plant, Voacanga megacarpa, afforded a 1:1 mixture of lupeol acetate (1) and β-amyrin acetate (1), and a 1:1 mixture of stigmasterol (3) and β-sitosterol (4). The compounds were identified through analysis of their NMR spectroscopic data and by comparison with reported literature data. This is the first report on the isolation and identification of these compounds from V. megacarpa. The crude DCM-methanolic and alkaloid extracts, and fractions (1 and 2) showed moderate inhibitory activity against Mycobacterium tuberculosis H37Rv (MIC50 = 64 μg/mL).
Macabeo, A., Garcia, K., de Guzman, C., Vidar, W., & Franzblau, S. (2015). Pentacyclic Triterpenoids and Steroids from Voacanga megacarpa. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6(2), 432-435.