Date of Completion
Bachelor of Science in Pharmacy
Antihypercholesterolemic, hepatotoxic, Buah Merah, Rats, Sprague Dawley rats, Diet, High-Fat
Twenty-five (25) hypercholesterolemic, male Sprague Dawley rats were divided into five groups, one control group and four treatment groups. The treatment groups are as follows, BMM (100 mg/mL and 200 mg/mL, Atorvastatin (10 mg/kg) and BMM + Atorvastatin (50 mg/mL + 10 mg/kg). All the treatments were administered once daily for seven days. The pecentage reductions of serum cholesterol are as follows: control - 23.4%, BMM 100mg/mL-29.5%, BMM 200 mg/mL-43.0%, Atorvastatin-43.7% and BMM + Atrovastatin-37.3%. Theses preliminary results indicate that BMM alone may be better than placebo in lowering serum cholesterol. However, no potentiating nor additive effects were observed when BMM is co-administered with Atorvastatin. The ALT and AST levels aere at 41.2 U/L and 110.2 U/L, respectively. These amounts are within the reported data on the ALT and AST levels for Sprague Dawley rats (Giknis and Clifford, 2006).
Timothy Jay L. Bengala, RPh
Bunquin, R. G., Dayrit, J. S., Dotillos, F. N., & Verallo, R. O. (2018, June). Antihypercholesterolemic activity and hepatotoxic effects of Buah Merah mix on male Sprague Dawley rats. GreenPrints. https://greenprints.dlshsi.edu.ph/bsp/26/