Date of Completion

6-2018

Document Type

Thesis

Degree Name

Bachelor of Science in Pharmacy

Keywords

Antihypercholesterolemic, hepatotoxic, Buah Merah, Rats, Sprague Dawley rats, Diet, High-Fat

Abstract

Twenty-five (25) hypercholesterolemic, male Sprague Dawley rats were divided into five groups, one control group and four treatment groups. The treatment groups are as follows, BMM (100 mg/mL and 200 mg/mL, Atorvastatin (10 mg/kg) and BMM + Atorvastatin (50 mg/mL + 10 mg/kg). All the treatments were administered once daily for seven days. The pecentage reductions of serum cholesterol are as follows: control - 23.4%, BMM 100mg/mL-29.5%, BMM 200 mg/mL-43.0%, Atorvastatin-43.7% and BMM + Atrovastatin-37.3%. Theses preliminary results indicate that BMM alone may be better than placebo in lowering serum cholesterol. However, no potentiating nor additive effects were observed when BMM is co-administered with Atorvastatin. The ALT and AST levels aere at 41.2 U/L and 110.2 U/L, respectively. These amounts are within the reported data on the ALT and AST levels for Sprague Dawley rats (Giknis and Clifford, 2006).

First Advisor

Timothy Jay L. Bengala, RPh

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