Title

Fourier transform infrared spectroscopic determination of spectral markers in commercial products of lagundi (vitex negundo L.)

Date of Completion

5-2018

Document Type

Thesis

Degree Name

Bachelor of Science in Pharmacy

Keywords

lagundi, Fourier transform infrared spectroscopic, spectroscopic

Abstract

Fourier-Transform Infrared (FTR) Spectroscopy is an identification method similar to the aforementioned methods of identification, and it has the ability to identify constituents of HMs within the fingerprint region of the spectra. Using Diffuse Reflectance Infrared Fourier-Transofrm (DRIFT) Spectroscopy, five different samples were tested and numerous spectra of Lagundi (Vitex negundo L.) was generated and analyzed to determine its distinct fingerprint region. Analysis of the patterns and trends of the spectra was then validated using chemomentric analysis with the aid of the software ChemoFace, a software from an institution in Brazil. Thin Layer Chromatography (TLC) was also used to see if the HMs complied with the existing standards in the Philippine Pharmacopoeia (PP). After all the tests conducted and data analyzed, it was seen that Lagundi has consistent wavenumbers appearing in all samples, has consistent peaks present, and has consistent data regardless of concentration and sample. By using these methods, the quality and safety of drugs can begin to be validated by the presence of significant wavenumbers unique in the fingerprint region.

First Advisor

Sigredo B. Mata, RPh

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