The screening of hypoglycemic activity of lactobacillus plantarum in alloxan-induced diabetic Sprague-Dawley rats

Date of Completion


Document Type


Degree Name

Bachelor of Science in Medical Laboratory Science


Diabetes, Rats, Lactobacillus plantarum, Alloxan


Alloxan was used to induce diabetes to the rats intraperitoneally. This study also evaluated the similarity of metformin efficacy in the Lactobacillus plantarum treatment. Rats were firstly induced with Alloxan intraperiotoneally to increase blood glucose levels of each. Animals were then treated orally with L. plantarum at high and low concentration at a span of 14 days. The results of the study showed that glucose levels after 14 days of treatment were then obtained, Group 1 which receive Metformin shows a decreased in glucose levels. Group 2 which received Normal Saline Solution, remained to have an elevated glucose level. While groups 3 and 4 which received the high and low dosage of Lactobacillus plantarum shows a significant decrease in the blood glucose level which is in lined and comparable on the hypoglycemic activity of the positive control which is the Metformin. The study concluded that Lactobaciullus plantarum shows a hypoglycemic activity in Alloxan-induced Sprague Dawley Rats after only 14 days of administering the treatment.

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