Date of Completion


Document Type


Degree Name

Bachelor of Science in Medical Laboratory Science


Tight Junctions, Serum zonulin, biomarker, Liver Diseases, liver damage


The study used convenience sampling as a method of choice for the sampling of population. In this method, the participants were selected on the basis of their availability and accessibility to the means of the researchers. This study tested blood ZO levels by using the Human Zonulin ELISA kit from MyBioSource, CA, USA. This study concluded that there has no statistically proven the significant correlation between variables such as age, sex and ALT levels with the serum Zonulin level activity. Further research is needed to completely understand the mechanism serum Zonulin plays in the development, pathogenesis, and progression of liver damage.

First Advisor

Ma. Gladys Aquino, RN, RMT, MPH, MLS