Date of Completion

7-2019

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

antidepressant, Plant Extract, Antidepressive Agents, Cynometra ramiflora

Abstract

This study was conducted to evaluate the potential antidepressant-like effect of a common ornamental plant native to the Philippines Cynometra ramiflora Linn, against depressive models taht were induced by in vivo assays: forced swimming test (FST) and tail suspension test (TST). The immobile state of male ICR albino mice in the two assays is comparable with the depressive state experienced by humans. In the phytochemical screening of crude ethanolic extract, the presences of effective antioxidants, phenolic compounds and flavonoids were confirmed. In the animal assays, the percent immobility duratins were recorded from the control group (saline solution), Standard Group (Fluoxetine), 700m,g/kg group, 850 mg/kg group, and 1000 mg/kg group of ethanolic extract. The ANOVA analysis obtained p-values that were less than 0.05 in both assays, which indicated the significant correlations upon the extract injection compared with the control group. However, the higher immobility in the variable groups than the control group indicates the negative effect, which might be explained by the low potency and chemical nature of composition of the crude extract. Therefore, further purification and quantification should be achieved to improve the efficacy of the extract to be an applicable herbal therapy.

First Advisor

Tabitha L. Amora, RCh, PhD

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