In vivo antipyretic and analgesic effects of the ethanolic extract of Bauhinia malabarica leaves in ICR albino mice

Date of Completion


Document Type


Degree Name

Bachelor of Science in Biochemistry




The increasing emergency room visits of about 421 for every 1,000 individuals in the population and the adverse effects associated with taking synthetic antipyretic or analgesic drugs. The most common reasons for ER visits were fever, chest pain and abdominal pain. The ethanolic extract of B. malabarica was subjected to phytochemical screening before in vivo assays. It was administered to male Institute of Cancer Research (ICR) albino mice in 700 mg/kg, 850 mg/kg and 1000 mg/kg doses. The mice were subjected to antipyretic and analgesic screening methods wherein the percent reduction in temperature and percent increase in reaction time are expressions of the antipyretic and analgesic effects. Phytochemical analysis revealed the presence of polyphenolic flavonoids, sterols and tannins. A decrease in the tail temperature after 3 hours indicated antipyretic effect as observed in the standard antipyretic paracetamol (25.77±0.07) and an increase in reaction time after 3 hours indicated analgesic effect in the standard analgesis aspirin (33.97±0.94) to which all the different doses of the extract were compared. Results revealed that all three doses decreased the tail temperature and increased the reaction time of mice in both tests as compared to the control (p

This document is currently not available here.