Title

In vivo antidepressant-like effects of the ethanolic extract Malvastrum coromandelianum (l.) Garcke leaves in ICR albino mice

Date of Completion

2018

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

Antidepressive Agents.

Abstract

The ethanolic extract of Malvastrum coromandelianum (L.) Garcke leaves in ICR albino mice in various doses such as 650 mg/kg, 750 mg/kg and 850 mg/kg. Furthermore, forced swimming test and tail suspension test were used to evaluate and observe the antidepressant-like activity of the ethanolic extract of Malvastrum coromandelianum (L.) Garcke leaves. A significant decrease in percent immobility was observed in both screening methods used. For the FST, there were significant negative 59.15% and 77.47% decrease in the immobility for dose 650 mg/kg at p,0.05 and 750 mg/kg at p,0.01, respectively, when compared to the control and standard. In TST, doses 650 mg/kg and 750 mg/kg showed a significant decrease in percent immobility and gave a negative 34.35% and 26.34% change, which were significant at P<0.01. Therefore, it is evident from the results of FST and TST that the ethanolic extract of Malvastrum coromandelianum (L.) Garcke leaves was able to decrease the duration of percent immobility of mice. However, further studies about the mechanism of action and pharmacological properties of the compounds responsible for the antidepressant-like effect are needed to strengthen the effectivity of the ethanolic extract of Malvastrum coromandelianum (L.) Garcke leaves.

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