Title

In vivo antidepressant-like effect of the ethanolic extract of Lagerstroemia speciosa leaves in ICR albino mice

Date of Completion

2018

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

Antidepressive Agents.

Abstract

The main objective of this study was to evaluate the potential antidepressant-like effect of the ethanolic extract of Lagerstroemia speciosa leaves. This study aims to focus on the prevalent issue of major depressive disorder affecting approximately 3.3. million Filipinos, and the negative symptoms linked with antidepressant medications. The antidepressant activity of the ethanolic extract of L. speciosa was evaluated through the forced swimming test (FST) and the tail suspension test (TST) with the doses of 700 mg/kg, 850 mg/kg and 1000 mg/kg in male IOCR albino mice. In both tests, mice resolve to a state of immobility which was related to behavioral despair associated with a depressive-like stat in humans. Subsequently, the percent immobility obtained in both tests was used to express the antidepressant-like effect of the treatment groups. Results revealed that the three extract dosage groups decreased the immobility time in both tests. In essence, the 850 mg/kg dosage showed the most significant decrease in percent immobility similar to that of the standard fluoxetine. This indicates the positive antidepressant-like effect of the extracts comaprable to the standard antidepressant drug. However, further studies are necessary to better understand the mode of action of L. speciosa as well as the identification and isolation of the active ingredient responsible for its antidepressant-like effect.

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