Date of Completion

7-2019

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

Lansium domesticum, ethanol extracts, Mus musculus domesticus, diuretic

Abstract

The current study aimed to investigate the diuretic effects of ethanol extracts of Lansium domesticum fruit peels on Mus musculus domesticus. An acute toxicity test was done to mice from a dosage of 250 mg/kg to 2000 mg/kg. The test showed no signs of mortality. An individual dose of ethanolic extract of L. domesticum fruit peel (500 mg/kg, 1000 mg/kg, 1500 mg/kg each), and furosemide (30 mg/kg each), a reference drug, were administered orally to dehydrated mice. Control group mice were fed with normal saline (20 mg/kg). All mice were grouped into six with assigned concentrations, place in metabolic cages and their urine output monitored at 6 hour intervals. The extract showed a little (500 mg/kg) to moderate (1000 mg/kg & 1500 mg/kg) diuretic effect on the mice.

First Advisor

Iluminada A. Ronio, LPT, MSc

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