Date of Completion

8-2020

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

M. tuberculosis, Multidrug-resistant M. Tuberculosis, Pyridomycin, InhA

Abstract

In this study, the researchers created five (5) new pyridomycin derivatives. The structures of the five (5) pyridomycin analogs were drawn using Chemdraw, minimized using Chem3D, and the best ligand pose and binding affinity were obtained using Autodock Vina. The results showed that derivative 1, which bears the cyclopentyl ring as part of the non-polar group, gave thehighest binding affinity (10.9 kcal/mol) with InhA. Derivative 4 and pyridomycin both produced a binding affinity of -9.9 Kcal/mol. The lowest binding energy was found in derivative 3, which had -9.3 Kcal/mol.

First Advisor

Margel C. Bonifacio

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