Date of Completion

6-2019

Document Type

Thesis

Degree Name

Bachelor of Science in Biochemistry

Keywords

Calocybe indica, Pleurotus ostreatus, duck chorioallantoic membrane, paclitaxel, angiosuppressive

Abstract

Food containing antioxidants inhibit the formation of new blood vessels that are responsible for tumor growth and metastasis. Calocybe indica (Cl) and Pleurotus ostreatus (PO) are edible mushrooms known for their good antioxidant property. The antiangiogenic effect of the ethanolic extracts of Cl and PO with and without paclitaxel was investigated on duck chorioallantoic membrane (CAM). The total number of blood vessel junctions on trated duck CAM were counted manually. The ethanolic extracts of PO, Cl, and paclitaxel had repressed angiogenesis by 20%, 11%, and 64% respectively. Whereas, the combination of PO and Cl with paclitaxel had inhibited blood vessel formation by 89% and 83% respectively suggesting a synergestic effect with 100% duck embryo survivability. Such effect may lead to a potent antiangiogenic treatment for tumor development and could possible enhance angiosuppressive activity of paclitaxel in a clinical setting.

First Advisor

Margel C. Bonifacio

Previous Versions

Feb 14 2021

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